New depsipeptide antibiotics from marine Streptomyces sp. KMM 9044

Picture from https://pubs.acs.org/doi/10.1021/acs.orglett.2c01714

Two new unusual depsiheptapeptides streptocinnamides were isolated from the bacterium Streptomyces sp. KMM 9044 collected in the northwestern part of the Sea of Japan. The structures of isolated compounds were identified by NMR and MS studies and confirmed by chemical transformations. One of the isolated compounds, streptocinnamide A is a potential selective inhibitor of a series of Gram-positive bacteria. The project was performed in collaboration with G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Pirogov Russian National Research Medical University, Moscow Institute of Physics and Technology and Federal Research and Clinical Centre of Physical-Chemical Medicine of Federal Medical Biological Agency. Further information could be found on OrgLett website.