Сhemical mechanisms of fluorescence
Fluorescent protein chromophores

Accomplished

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1) Mechanism of DsRed chromophore formation

Ivashkin PE, Lukyanov KA, Lukyanov S, Yampolsky IV. A synthetic GFP-like chromophore undergoes base-catalyzed autoxidation into acylimine red form. J Org Chem (2011), 76 (8) 2782–2791.

 
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2) Insight into the mechnism of GFP chromophore fluorescence: conformationally-locked chromophore

Baranov MS, Lukyanov KA, Borissova AO, Shamir J, Kosenkov D, Slipchenko LV, Tolbert LM, Yampolsky IV, Solntsev KM. Conformationally locked chromophores as models of excited-state proton transfer in fluorescent proteins. J Am Chem Soc (2012), 134 (13) 6025–6032.

 

3) Development of WasCFP - a fluorescent protein with a tryptophan-based chromophore, which can exist in the anionic state

Sarkisyan KS, Yampolsky IV, Solntsev KM, Lukyanov SA, Lukyanov KA, Mishin AS. Tryptophan-based chromophore in fluorescent proteins can be anionic. Sci Rep (2012), 2 (0) 608.

 
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4) Cell-permeable fluorogenic dyes for live-cell protein labeling.

Bozhanova NG, Baranov MS, Klementieva NV, Sarkisyan KS, Gavrikov AS, Yampolsky IV, Zagaynova EV, Lukyanov SA, Lukyanov KA, Mishin AS. Protein labeling for live cell fluorescence microscopy with a highly photostable renewable signal. Chem Sci (2017), 8 (10) 7138–7142.