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RESEARCH


CURRENT

  • Studying bioluminescence of marine worms Chaetopterus variopedatus

червь

    Photograph courtesy Dimitri Deheyn, Scripps Institution of Oceanography at UC San Diego.
  • Studying bioluminescence mechanism of Siberian earthworms Fridereicia heliota

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    (A) Structure of Fridereicia luciferin. (B) Bioluminescence of Fridericia heliota . The photograph is courtesy of Alexander Semenov (White Sea Biological Station, Biology Department of Lomonosov Moscow State University). (C) Luminescence of synthetic Fridericia luciferin . (D) Comparison of in vivo bioluminescence spectra of worms, with in vitro bioluminescence spectra of natural and synthetic samples of luciferin.
    Angew. Chem. 2015
    Angew. Chem. 2014
  • Development of anti-influenza drug candidates based on structural analogs of Flutimide

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  • Enantioselective total synthesis of fungal terpenoid panal from bioluminescent fungus Panellus stipticus

    грибы 2
    Panellus stipticus
     
  • Studying luminescence mechanism of luminous fungi.

  • омфалотус

  • Studying biosynthetic origin of marine luciferins: coelenterazine and Cypridina luciferin

    рачокс 4
    Cypridina hilgendorfii

  • Developing fluorogenic sensors to important protein targets

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FULFILLED

2011-2015
Development of novel class of fluorescent dyes based on GFP chromophore

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J. Am. Chem. Soc., 2012

2009-2011
Biosynthetic mechanism of chemically unstable acylimine chromophore of red fluorescent proteins was investigated. This required development of new synthetic strategy to 2-acylaminoimidazolones - biosynthetic precursors of 2-acyliminoimidazolones. We have shown spontaneous oxidation of precursors with air oxygen by unusual mechanism

дискосома формула
Discosoma

J. Org. Chem. 2011

 

 

2002-2009
Total synthesis of chromophores of GFP-like fluorescent proteins was used as a tool for independent structure determination of these chromophores. Also, this allowed to study structure-spectral properties relationship within this range of imidazole derivatives and to develop novel synthetic approaches to 2-functionalized arylideneimidazolones. Chromophores of AsFP595, Kaede and YFP538 were synthesized

коралл
if
Zoanthus
 
kr_kor
kaede
Trachyphyllia
 
anemon
aspf
Anemonia


Biochem. 2005
Bioorg. Chem. 2008

2002-2004
A blue proteinaceous pigment from Rhizostoma pulmo (jellyfish from the Black Sea, Fig. 1) was isolated, sequenced and studied by biochemical methods. An attempt to determine the nature of the blue coloration (chromophore) was unsuccessful.

медуза
3
Black Sea jellyfish Rhizostoma pulmo possessing an unidentified blue pigment
J. Biol. Chem. 2004

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institute of Bioorganic Chemistry